Yapay insan DNA’sı İçin Büyük Hamle !




Bilimdeki en büyük ahlâki tartışmalarından biri olan hayatın temel yapı taşlarının değiştirilmesi konusu bir kez daha tartışmaya açıldı.

İnsan genomunu temelden yazmak konusunda iddialı ve tartışmalı bir plan hazırlayan bilim insanlarına göre, DNA sentezleme ve onu memelilere ve hatta insan hücrelerine dahil etme pratiği en fazla dört-beş yıl uzakta. Genetik ve biyomühendisl

 

ik alanındaki yaklaşık 200 önde gelen araştırmacı New York City’de gerçekleşen bir toplantıda Genome Project-write (Genetik Kodları Yazma Projesi / GP) planının sonraki aşamaları görüşüyor. Araştırma amacıyla yüz milyon Amerikan Doları ayrılan girişim, insan genomu da dahil olmak üzere, canlı organizmalar üzerinde mühendislik ve test çalışmalarını içeriyor.

Projede yer alanlar, projeyi genom bilimi konusundaki anlayışımızı geliştirmek için tasarlanan açık, uluslar arası bir işbirliği biçiminde tanımlarken, GP yazma alanın bir yıl önce gerçekleştirilen ilk büyük buluşmanın neredeyse gizli olarak seçilmiş bir grupla gerçekleştirilmesinin ardından, kapalı kapılar ardında görüşmeler yapan uzmanlarla ilgili ciddi tartışmalar yaşanmıştı.


GERÇEKLEŞMESİ DÖRT-BEŞ YILI BULABİLİR

Başarıyla sentezlenen DNA mayası ile sıfırdan yapay insan DNA’sı yaratmak noktası arasında büyük bir mesafe söz konusu olabilir. Ancak genel amaç, nihai sonuca ulaşmadan önce nispeten basit olan genetik kodların (mikrop ve bitki DNA’sı gibi) nasıl sentezleneceğini bulmak. Boeke, “Bunu başarırsanız, karmaşık bir aracın nasıl işlediğine ilişkin çok daha derinlikli bir kavrayış kazanırsınız” diyor. “Gerçekten de sentetik bir genom, yeni bilgiler edinmek için öenmli bir araçtır.”

 
GP yazımı, yeni örgütsel yapısı içerisinde, insan genomlarının bütünüyle veya kısmen sentezlenmesini amaçlayan İnsan Genom Projesinin temel alanını (yazan HGP yazısı) içeren ana projedir. Projenin asıl hedefi bitki, hayvan ve insan DNA’sının sentezlenmesinin dışında, genom mühendisliğinin maliyetini azaltmaktır.


DNA inceleme laboratuvar ile ilgili görsel sonucu


MALİYETİ ÇOK YÜKSEK

Günümüzde, DNA’mızı oluşturan her baz poliükleobaz molekülünü sentezlemek için yaklaşık 10 sent harcama yapıldığı tahmin edilmektedir ve insanlara gelince; bu molekül çiftlerinden yaklaşık 3 milyar tane olduğu düşünüldüğünde; sentez faaliyeti oldukça pahalı bir süreçtir. Plan, bu maliyeti on yıl içerisinde bin kattan daha ucuza yapabilmek yönünde.

 

Elbette bunun gerçekleşmesi için GP yazımı organizatörlerinin; önümüzdeki hafta yapacakları toplantıların bir diğer ihtiyaç olan yaklaşık 100 milyon ABD dolarlık bütçeyi sağlamaları gerekmekte. Şimdiden heyecan yaratan bu girişim, önümüzdeki yıllarda GP yazma konusunda çok daha fazla tartışmaya neden olacaktır.

 

Yazı Derleme : Tarkan Tufan Gazeteduvar-Biyologlar

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