Yeni Tiroid Hücreleri Tasarlandı



Araştırmacılar, tiroid hücrelerini üretmek için yeni ve verimli bir yol keşfetti,Tiroid olarak bilinen ve genetik olarak modifiye edilmiş embriyonik kök hücreler kullanılarak yeni tiroid hücreleri oluşturulmuş oldu.


Kök Hücre Raporları dergisinde çıkan bulgular eşliğinde görülüyor ki; Tiroid hastalığının modellenmesinin doğru yapılamıyor olmasının nedenlerini ve tedavilerin gelişimini daha iyi anlamak için; insan kök hücreleri kullanarak benzer bir protokol geliştirmenin öncelikli bir çalışma olacağı belirtiliyor.

Tiroid rahatsızlıkları, ABD'nin yaklaşık yüzde 10'unu etkilemektedir. Bu durum ülkemizde de denize kıyısı olasından dolayı; ayrıca deniz mahsüllerini tüketme yoğunluğundan mütevellit türk insanının da dertleri arasında olan bir hastalık olarak göze çarpmaktadır. Grave hastalığı veya Hashimoto hastalığı bu kapsama dahildir; Hipertoni veya hipotiroidizme neden olabilir,tiroid nodülleri meydana gelir ve guatr veya kanser olarak seyirini devam ettirebilir.





Boston Üniversitesi Tıp Fakültesi'nden (BUSM) araştırmacılar, Laboratuvarda belirli bir genin genetik anahtarını ifade etmek üzere kültüre edilmiş;  fare embriyonik kök hücreleri kullanılarak tasarlama işlemi çalışmları yapılarak  tiroid tanısına ve tedavisine direkt saptama yapılabilecek bir adım atılmış oldu.

Nkx2-1, Bu tiroid gelişimi için kilit rol oynayan yapılardan biri olarak nitelendirilebilir.Daha sonra embriyonik kök hücreleri çeşitli aşamalarla yönlendirme işlemine tabi tutulur; Kısa süre içerisinde Nkx2-1'i açıp kapatma ilemine tabi tutarak, bu genin açılmasıyla; hücrelerin büyük bir kısmını tiroid hücrelerine dönüştüren dar bir zaman çizelgesi tespit edilmiş oldu.

İlgili resim
BUSM'de tıp profesörü ve Boston Tıp Merkezi ve BUSM'da Rejeneratif Tıp Merkezi (CReM) üyesi olan Dr. Laertis Ikonomou  Konuya şöyle açıklama getiriyor ;

 

'' Bu yöntem, hedef hücre türünün yüksek verimi ile sonuçlanmış oldu; Tiroid hücreleri, Ancak akciğer hücreleri gibi diğer klinik durumlarla ilişkili hücre tiplerinin türetilmesi için de geçerli olarak kullanılabilir, İnsülin üreten hücreler, karaciğer hücreleri vb. ''

 

Araştırmacılar, bu çalışmanın tiroid ve diğer bu temele dayanan bozukluklara maruz kalmış birçok insanın yaşam kalitesini artıracak terapötiklerin veya kök hücre / genetik mühendislik teknolojilerinin geliştirilmesine yol açacağına dair; kesin unutlar taşımasına zemin hazırlıyor. Bu yapının ve hareketliliğin tespiti ile nokta müdaheler şle birlikte tirod rahatsızlığı çeken pek çok insana çözüm olacağa benziyor.

 


Çeviri-Derleme : Mehmet Eraslan


KAYNAK :



  1. Keri Dame et al. Thyroid Progenitors Are Robustly Derived from Embryonic Stem Cells through Transient, Developmental Stage-Specific Overexpression of Nkx2-1Stem Cell Reports, February 2017 DOI: 10.1016/j.stemcr.2016.12.024





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